We consider the impact of a 4th generation on Higgs to two-photon and WW,ZZ signals and demonstrate that the Tevatron and LHC have essentially eliminated the possibility of a 4th generation if the Higgs is SM-like and has mass below 200 GeV. We also show that the absence of enhanced Higgs signals in current data sets in the two-photon and WW,ZZ final states can strongly constrain the possibility of a 4th generation in two-Higgs-doublet models of type II, including the MSSM.